Job Description
Job Title : Sr. Scientist
Location : Bothell, WA
Compensation: $37.45- $43.86
Type: Contract
Overview Leading pharmaceutical company looking for a Sr. Scientist. Ideal candidates should have a PhD or equivalent experience in bioanalytical chemistry, analytical chemistry, pharmaceutical sciences, or a related discipline with recognized and established expertise in mass spectrometry. Additionally 4+ years of research experience in the biotech/pharmaceutical industry or closely related academic areas.
Responsibilities - Determine and develop novel and appropriate LC-MS methods for the characterization of intact ADCs, antibodies, and other proteins
- Develop and optimize both broadly applicable and fit-for-purpose methodologies for the capture, characterization, and quantification of proteins and conjugates from biological samples
- Perform peptide mapping to deeply characterize proteins and bioconjugates
- Provide care, maintenance, and troubleshooting of shared LC-MS instrumentation, including training new users and developing and maintaining best practices
- Provide technical and scientific advice and support to scientists of all levels, advise on LC and mass spectrometry related questions, and provide sample processing and data analysis for non-MS users
- Practice continuous improvement to refine methods and optimize processes, staying in touch with relevant literature and state of the art technologies
- Maintain strong communication and collaborative relationships with mass spectrometry groups outside of Research
- Create and organize technical information to deliver effective presentations in multiple forums
Requirements EDUCATION AND EXPERIENCE:
- A Ph.D. or equivalent experience in bioanalytical chemistry, analytical chemistry, pharmaceutical sciences, or a related discipline with recognized and established expertise in mass spectrometry
- 4+ years of research experience in the biotech/pharmaceutical industry or closely related academic areas
- Demonstrated experience in the operation and maintenance of mass spectrometers, their software, and applicable data analysis software
- Established capability in biological characterization and data analysis, specifically utilizing mass spectrometry techniques
- Attention to detail and a strong analytical mindset capable of proposing sound experimental strategies and developing new LC-MS protocols
- Uses critical thinking to solve complex problems, address challenges, overcome obstacles, and anticipate areas for growth
- Established safe laboratory skills and accurate record keeping
- Ability to work independently on routine experiments
TECHNICAL SKILLS REQUIREMENTS:
Preferred qualifications include:
- Hands-on experience working with a Waters Xevo G2S QTof, Thermofisher Q Exactive, and/or SCIEX X500B QTOF
- Familiarity with affinity purification of proteins, peptides and/or metabolites.
- Experience analyzing all types of recombinant proteins
- Experience identifying and characterizing post-translational modifications or enzymatic modifications of proteins
- Experience with protein conformational analysis, such as Hydrogen deuterium exchange mass spectrometry
- Familiarity with Protein Metrics software and reporting, including high throughput data processing
- Experience or familiarity with mass spectrometry automation
- Knowledge of SEC-MALS biological analysis methods
Benefits System One offers eligible employees health and welfare benefits coverage options, including medical, dental, vision, spending accounts, life insurance, voluntary plans, and participation in a 401(k) plan. Ref: #558-Scientific
Job Tags
Contract work,